Complete versus target vessel revascularization in ST-elevation myocardial infarction—analysis of results from published meta-analysis of randomized controlled trials

We thank Weng et al. for their interest in our recent paper where we performed an updated meta-analysis of the benefits of non-culprit revascularization during an ST elevation myocardial infarction (STEMI) (1). The authors used trial sequence analysis (TSA) to further explore the results of our meta-analysis. The results of their TSA (2) confirmed the lower incidence of major adverse cardiac events and repeat revascularization among patients undergoing non-culprit lesion intervention. They also hypothesized that our finding of similar all-cause mortality may be a type II error (false negative) and the demonstration of lower myocardial infarction may be a type 1 error (false positive).