Say goodbye to Martini and Melamed: genomic classification of multiple synchronous lung cancer

It is said that all good things must come to an end. The paper “Genomic heterogeneity of multiple synchronous lung cancer” by Liu et al. may finally close the book on the Martini and Melamed criteria for establishing whether multiple synchronous lung cancers (MSLC) represent distinct primary tumors or intrapulmonary metastases (1).