Intratumoral heterogeneity of esophageal squamous cell carcinoma

Dirk Walter

Abstract

The advent of large scale genome characterization led to rapidly increasing knowledge of genetic landscapes of malignancies in recent years. Besides a difference in quantity of mutations between different entities, studies revealed as well a difference in the amount of mutations in varying locations of a single neoplastic lesion: the relation of private (only present in a single sample of a tumor) and common mutations (present in all tested samples of tumor) can vary markedly (1-3).