Uniportal video-assisted thoracoscopic thymectomy and resection of a giant thymoma in a patient witness of Jehova

A rare case of a giant thymoma in a patient witness of Jehova treated by single port thoracoscopic resection is reported. A 78-year-old man with chest pain and mild dyspnea had been previously diagnosed with giant thymoma went to our hospital and asked for second opinion of operation. Computed tomography showed a 12.5 cm × 9.5 cm × 10 cm mass in the anterior mediastinum. Under the request of this patient, he is only willing to receive minimal invasive surgery without blood transfusion. Thirty-six hours after surgical resection, the patient safely discharged from our hospital without complication. Pathological diagnosis indicated a thymoma without capsular invasion, and a diagnosis of Masaoka stage I thymoma was made. Giant mediastinal thymoma is not rare, but how to perform minimal invasive surgery without complication and blood transfusion is a great challenge even for an experienced surgeon.