ATHOS-3 and the knights of the round table—the search for the holy grail of vasopressors

Michael Hessler, Philip-Helge Arnemann, Laura Seidel, Tim Kampmeier, Sebastian Rehberg, Christian Ertmer


The international, multicentre, double-blinded, randomized, controlled ATHOS-3 trial by Khanna and colleagues (1) was conducted from May 2015 to January 2017 in nine countries across Europe, North America, and Australia. ATHOS-3 was designed to answer two primary endpoints within a study period of 48 h.