Molecular mechanisms of pathological tumor transformation and their clinical implications: predictors of pulmonary adenocarcinoma transformation into small cell carcinoma

Maria-Rosa Ghigna, Vincent Thomas De Montpréville


Lee et al. have recently described predictors of transformation into small-cell carcinomas from lung adenocarcinomas under treatment by tyrosine kinase inhibitor (1). Their very interesting work raises several reflections about tumor transformation and the clinical management of tumor drug resistance.