Diagnostic implication of fibrin degradation products and D-dimer in aortic dissection—author’s reply

Shuangshuang Li, Jian Dong, Lei Zhang, Zhiqing Zhao, Rui Feng, Qingsheng Lu, Jian Zhou, Junmin Bao, Zaiping Jing


Acute aortic dissection (AAD) is a life-threatening disease requiring an early diagnosis and rapid treatment to prevent death. The annual incidence of AAD was about three cases per 100,000, with a high mortality rate of 24.4% for type A and 10.7% for type B without urgent treatment (1). About 20% AAD patients were with non-specific symptoms, and up to 40% of patients were undiagnosed until necropsy (2). Given the atypical presentations and time dependent mortality, sensitive and quicker predictive diagnosis methods are paramount to take rst-aids measures.