Spread through air spaces—novel pattern of cancer progression
Despite the proliferation of antismoking campaigns and lung cancer screening by computed tomography, lung cancer remains the leading cause of cancer death worldwide. Because of the anatomical features of the lung, the growth patterns of lung malignancies differ from malignancies of other sites. The patterns of lung cancer progression are cancer spread via vascular, lymphatic, or alveolar spaces (1). These are related to the biological behavior of the lung tumor.