Regenerative concepts in cardiovascular research: novel hybrid therapy for remodeling ischemic cardiomyopathy

Treatment for coronary artery disease includes medical management, percutaneous coronary interventions (PCI), and coronary artery bypass grafting. However, despite optimal medical therapy and revascularization, ischemic cardiomyopathy is responsible for 538,000 deaths per year in the U.S. alone (1). Stem cell transplantation provides an opportunity to reduce mortality through its potential to fully heal and replace infarcted myocardium.