Article Abstract

Breast carcinoma is a multifactorial disease involving FOXN3, SINA3 and NEAT through repression of GATA3 and TJP

Authors: Dina Sabry, Abeer Mostafa, Amira Hassouna


Forkhead box (Fox) proteins are a superfamily of transcriptional regulators, which control a wide range of biological processes, therefore, a disturbance of Fox activity can alter cell development, initiate tumorogenesis and cancer metastasis. There are several Fox subfamilies such as FoxN, FoxO, FoxM, FoxP, FoxC and FoxA that are involved in tumor development and progression.