Serial chest CT findings of intravascular large B-cell lymphoma of the lungs

Intravascular large B-cell lymphoma (IVLBCL) is a rare variant of diffuse large B-cell lymphoma that is characterized histologically by proliferating mononuclear cells within the lumens of capillaries, venules, arterioles, and small arteries (1,2). This is an aggressive lymphoma with poor prognosis that contributes to delays in diagnosis because of the variable symptoms (1). IVLBCL of the lung is mostly detected at autopsy due to rarity (3). Chest computed tomography (CT) findings of IVLBCL include bilateral diffuse ground glass attenuation (GGA) in the whole lung, but this is nonspecific and can be seen in patients with diverse diseases, which can cause delayed diagnosis of this rapidly progressive and diffuse vascular tumorous condition (3,4). There are no reports about serial chest CT and 18F-fluorodeoxyglucose (FDG) positronemission tomography-CT (PET-CT) findings of IVLBCL, which could help to differentiate this unusual vascular lymphoma from diffuse lung disease.