Article Abstract

Squamous cell carcinoma transformation from adenocarcinoma as an acquired resistance after the EGFR TKI therapy in (EGFR-mutated) non-small cell lung cancer

Authors: Shinji Shinohara, Yoshinobu Ichiki, Yukiko Fukuichi, Yohei Honda, Masatoshi Kanayama, Akihiro Taira, Yusuke Nabe, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Kazue Yoneda, Hirotsugu Noguchi, Fumihiro Tanaka

Abstract

Lung cancer remains the leading cause of cancer mortality worldwide. The incidence of recurrence or distant metastasis after complete resection of primary tumors is reported to be 37%, even in patients with stage I non-small cell lung carcinoma (NSCLC) (1).