Sarcopenia in resected non-small cell lung cancer: let’s move to patient-directed strategies

Philippe Icard, Antonio Iannelli, Hubert Lincet, Marco Alifano

Abstract

Sarcopenia is a loss of skeletal muscle mass, quality and function associated with poor nutrition, ageing, sedentarity, and chronic diseases, in particular chronic obstructive pulmonary disease (COPD) and malignancies (1). In cancer, the association of sarcopenia with poor nutrition, lipolysis, inflammatory status and vicious metabolic cycles promote the occurrence of cachexia, a nutritional and psychological condition considered as the direct cause of death in at least 20% of patients with advanced cancers (2-4).