Article Abstract

Two-edged sword: how activation of the “proto-oncogene” yes-associated protein 1 in lung squamous cell carcinoma can surprisingly inhibit tumor growth

Authors: Thomas Andl, Claudia D. Andl, Yuhang Zhang


The Hippo signaling pathway is a highly conserved pathway that regulates cell proliferation and apoptosis. The core components of the pathway, a cascade of protein serine kinases, are commonly present in most eukaryotic organisms (1).