Article Abstract

Dual role of YAP: oncoprotein and tumor suppressor

Authors: Eekhoon Jho


YAP (Yes-associated protein) is a terminal mediator of the Hippo signaling pathway. Hippo signaling is known as a key regulator of organ size by its ability to control cell proliferation and apoptosis (1,2). The Hippo gene was named after the mutant eye overgrowth phenotype in Drosophila which resembles the shape of a hippopotamus (3,4).