Mitochondria in β-adrenergic signaling: emerging therapeutic perspectives in heart failure and ventricular arrhythmias

We read with great interest the editorial article “Electrical storm: mechanistic and therapeutic considerations to avoid death in the survivors” by Tsuji and Dobrev which brings into spotlight mitochondria as an emerging and significant determinant of heart failure (HF) outcome. Despite the fact that current treatments for HF as well as electrical storm treatment do not directly target mitochondria, it would be interesting to approach their effects on them, with focus on β-adrenergic signaling.