Article Abstract

The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics

Authors: Aysegul Balyimez, Kevin L. Stephans, Mohamed E. Abazeed, Omar Y. Mian

Abstract

The hallmarks of established cancers have been meticulously catalogued over decades, almost entirely through the study of advanced disease (1). By contrast, the molecular features of early pre-neoplastic lesions including the occult alterations that presage progression to invasive and metastatic cancer, remain elusive (2). A better understanding of the biology of nascent cancers and the complex genetic and epigenetic evolutionary processes that drives them towards lethal disease, represents an important step towards more effective early intervention strategies.