Article Abstract

PEEP titration guided by transpulmonary pressure: lessons from a negative trial

Authors: Fernando Suarez-Sipmann, Carlos Ferrando, Jesús Villar

Abstract

Since the first description of the acute respiratory distress syndrome (ARDS) by the landmark paper of Ashbaugh et al. (1), the adequate use of positive end-expiratory pressure (PEEP) has been surrounded by a vivid controversy. This stems from the fact that its beneficial effects on oxygenation by re-aerating collapsed or flooded airspaces, may be counterbalanced by potential adverse effects on hemodynamics and on the risk of increasing lung tissue mechanical stress.

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