Eggs, dietary cholesterol, and cardiovascular disease: the debate continues

Our group recently published a study in the Journal of the American Medical Association, reporting that higher consumption of eggs or dietary cholesterol was associated with higher risk of cardiovascular disease and mortality in US adults (1). The publication of this result has triggered a new round of discussion and debate regarding the health concerns of egg and dietary cholesterol consumption. As discussed in the article (1) as well as related editorials (2,3), this is an observational study with limitations, although we pooled together a large diverse sample and implemented rigorous methodologies to analyze the data. In this editorial, I plan to cover several issues that are not discussed in the published article due to space constraints (1).