020. Coexistence of lung adenocarcinoma and usual interstitial pneumonia: a case report
The Pan Hellenic Congress Abstracts

020. Coexistence of lung adenocarcinoma and usual interstitial pneumonia: a case report

Aggeliki Baliaka1, Styliani Papaemmanouil1, Dionysis Spyratos2, Paul Zarogoulidis2, Leonidas Sakkas1

1Department of Pathology, General Hospital “G. Papanikolaou”, Thessaloniki, Greece; 2Pulmonary-Oncology, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece


Background: Usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown cause. The most common symptoms are progressively increased shortness of breath and dry cough. Some studies suggest an association between usual interstitial pneumonia and lung cancer through different pathogenetic mechanisms.

Objective: The case presentation of a patient with lung adenocarcinoma and UIP.

Methods: A 66-year-old male presented with persistent dry cough, hemoptysis and dyspnea. The chest radiographs revealed a mass in the lower lobe of the left lung, measuring 3 cm, as well as diffuse interstitial changes in the same lobe. Two partial lobectomies were performed.

Results: Histological examination of the mass showed moderately differentiated adenocarcinoma, focally with bronchoalveolar pattern (Immunohistochemical detection of EGFR: positive). The rest lung parenchyma presented histological appearance of UIP.

Conclusions: According to clinicopathological studies, the prevalence of lung cancer among patients with UIP/IPF varies between 4% and 9%. The overall median survival of IPF-Ca patients is seven months in comparison with IPF only patients (14 months).

Keywords: Lung cancer; interstitial lung disease; adenocarcinoma


doi: 10.3978/j.issn.2072-1439.2015.AB020


Cite this abstract as: Baliaka A, Papaemmanouil S, Spyratos D, Zarogoulidis P, Sakkas L. Coexistence of lung adenocarcinoma and usual interstitial pneumonia: a case report. J Thorac Dis 2015;7(S1):AB020. doi: 10.3978/j.issn.2072-1439.2015.AB020

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