030. Clinical phenotypes in asthmatic population with severe asthma
The Pan Hellenic Congress Abstracts

030. Clinical phenotypes in asthmatic population with severe asthma

Despina Ioannidou, Evangelia Fouka, Konstantinos Porpodis, Kelli Domvri, Konstantinos Zarogoulidis, Despina Papakosta

Department of Pneumonology, General Hospital G.Papanikolaou, Aristotle University of Thessaloniki, Exohi 57010, Thessaloniki, Greece


Objective: Assessment of clinical characteristics of severe asthma.

Methods: Retrospective study of the medical records of 3850 patients followed in our Asthma Clinic during the previous five years.

Results: 78 patients, 56 women and 26 men, mean age was 53.51±14.24 years (range, 20-81 years), suffering from severe asthma according to the 2014 ERS/ATS criteria, were found. Average body mass index (BMI) was 30.31±6.47, with 33% of subjects exhibiting BMI >30. Regarding pulmonary function testing (PFT), mean FEV1 was 81.10%±21.38% predicted, FVC: 89.78%±19.09%, FEV1/FVC: 75.19%±11.63, RV: 96.85%±31.98% and TLC: 89.51%±13.59%. 33 patients exacerbated during the previous year, while 12 of them required hospitalization. Average onset of asthma was 38 years and the mean duration of symptoms was 14.97±11.06 years. 17 patients reported a family history of asthma, 12 were current and 14 ex-smokers. Rhinitis was found in 34, nasal polyps in 12, aspirin intolerance in seven and clinical Gastroesophageal reflux disease (GERD) in three patients. Atopy was documented in 39%, with 25 patients demonstrating positive skin tests to pollens (Olive: nine, Grasses: seven, Chenopodium: three, Parietaria: three, various other pollens: three), 17 to mites, two to Alternaria, two to dog dander and 12 to other allergens. Occupational asthma was recorded in two and bronchospasm during exercise in six patients. 31 patients underwent High-resolution computed tomography (HRCT) imaging; major findings were centrilobular nodules, mosaic pattern, ground glass opacities, bronchial thickening, bronchiectasis and emphysema. All patients were receiving high doses of inhaled corticosteroids, 79% >1200 mcg of budesonide equivalent (1,600±600 mcg), while eirht patients were on permanent treatment with oral corticosteroids, at an average dose of 8.64±2.38 mg. Furthermore, all patients were receiving LABAs, 22 tiotropium, 19 montelukast and, finally, 17 patients omalizumab. Eventually, asthma control was not achieved in 30% of patients (ACT ≤19).

Conclusions: The incidence of severe asthma in our cohort was estimated approximately in 2%. Late-onset, non-allergic, obese and female predominant were the most common clinical phenotypes.

Keywords: Asthma; bronchodilators; spirometry


doi: 10.3978/j.issn.2072-1439.2015.AB030


Cite this abstract as: Ioannidou D, Fouka E, Porpodis K, Domvri K, Zarogoulidis K, Papakosta D. Clinical phenotypes in asthmatic population with severe asthma. J Thorac Dis 2015;7(S1):AB030. doi: 10.3978/j.issn.2072-1439.2015.AB030

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