AB 18. New dilemmas in small cell lung cancer tnm
clinical staging small cell lung cancer independent
Background: Many patients with Limited Disease (LD) behave
similarly to those with Extensive Disease (ED) from the prognostic
point of view. On the other hand, a proportion of patients with EDSCLC
behave similarly to those with LD.
Patients and methods: In this retrospective study analysis 764
patients with proven SCLC were included and managed with the same
therapeutic protocols. Of these patients, 278 (36.4%) has LD, while 486
(63.6%) had ED.
Results: No statistically significant difference was observed for survival
for IA and IB disease stage (P=0.254) and between IIA and IIB stage
(P=0.256) according to the new TNM classification. In addition, no
statistical significant difference was observed for survival between stage
(IIA+IIB) and IIIA stage (P=0.951), (IIA+IIIA P=0.658) and (IIB+IIIA
P=0.573). Statistical significant difference was observed for survival
among the LD SCLC patients with (IA+IB), (IIA+IIB+IIA) and IIB
stage (P<0.001). Similarly, statistical significance was observed for ED
SCLC patients with (IIA+IIB+IIIA), IIIB and IV stage (P<0.001).
Conclusions: Stratification of SCLC patients in LD and ED, although
generally satisfactory, has specific limitations, and therefore a new four
stage classification for SCLC should be established.
Cite this abstract as: Zarogoulidis K, Latsios D, Porpodis K, Zarogouldis P,
Darwiche K, Antoniou N, Eleftheriadou E, Boutsikou E, Tsakiridis K, Kontakiotis
T. New dilemmas in small cell lung cancer tnm clinical staging small cell lung
cancer independent evaluation. J Thorac Dis 2012;4(S1):AB18. DOI: 10.3978/