AB 58. The current role of 3-D conformal radiotherapy in syndrome of vena superior. The experience in Univercity General Hospital of Thessaloniki, AHEPA
Abstract

AB 58. The current role of 3-D conformal radiotherapy in syndrome of vena superior. The experience in Univercity General Hospital of Thessaloniki, AHEPA

Styliani Stylianidou1, Spyridon Domoxoudis1, Konstantinos Kyratzopoulos1, Anastasia Hatzigiannaki2, Ioannis Tzitzikas1, Kyriaki Pistevou-Gompaki1

1Department of Radiotherapy-Oncology, University General Hospital “AHEPA”, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Department of Medical Physics, University General Hospital “AHEPA” , Aristotle University of Thessaloniki, Thessaloniki, Greece


Background: The syndrome of Vena Cava Superior (SVCS) usually is caused from tumor-mass of lung cancer, which blockage the vena cava superior. Appears with swelling in face, redness, and dyspneia. It is an urgent condition in medical clinical Oncology and demands urgently external beam radiotherapy. The immediately current role of 3D Conformal external radiotherapy in Syndrome of Vena Cava Superior.

Patients and methods: A total of 16 patients with lung cancer and Syndrome of Vena Cava superior came in Department of Radiation therapy in U.G.H.TH.AHEPA, in the period 2010-2012. 6 patients revealed acute symptoms (swelling, dyspneia). A total of 10 patients revealed incipient Syndrom of vena cava superior. Computered Tomography of Thorax showed tumor mass which caused blockage in the vena cava superior, in all of the patients. It has been made biopsy and it was excluded the diagnosis of Lymphom or tumor of genital cells. All of the patients were submitted immediately in CT-Simulator equation, 2D-3D Conformal Treatment Planning with linear accelerator with MLC-multilief Collimator (blocks for protection the organs at risk (OAR)-heart, spinal cord, unilateral lung. Patients with incipient Syndrome received 10 fractions with 300 cGy/fraction in two weeks (3.000 cGy). Patients with already installed Syndrome V.C.S. (with acute symptoms) received in the first two fractions 400 cGy/fraction and they continued with 6 fractions with 300 cGy/fraction. Total dose was 2.600 cGy.

Results: Patients were rehabilitated their respiratory function after the second fraction. Swelling and redness in the face were not appear after third fraction. A total of 14 patients after the end of radiotherapy were in excellent performance status. In 2 patients the minimal dyspneia was disappeared two weeks after the end of radiotherapy. One month after the end of radiotherapy the CT of thorax showed reduce of the tumor mass. Respiratory function was in complete rehabilitation.

Conclusions: The immediately urgently external beam radiotherapy, in a few days and high dose, compose an excellent therapeutical approach for the patients with Syndrom of Vena Cava Superior. Relieves from the symptoms in patients, increasing their overall survive and give improvement in the quality of life.

Cite this abstract as: Stylianidou S, Domoxoudis S, Kyratzopoulos K, Hatzigiannaki A, Tzitzikas I, Pistevou-Gompaki K. The current role of 3-D conformal radiotherapy in syndrome of vena superior. The experience in Univercity General Hospital of Thessaloniki, AHEPA. J Thorac Dis 2012;4(S1):AB58. DOI: 10.3978/ j.issn.2072-1439.2012.s058

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