Optimal sequencing of postoperative radiotherapy and chemotherapy in IIIA-N2 non-small cell lung cancer

Lee et al. questioned the optimal sequencing of postoperative radiotherapy (PORT) and postoperative chemotherapy (POCT) after surgery for patients with IIIA-N2 non-small cell lung cancer (NSCLC) which was left untested in a prospective randomized setting (1); and performed the PORT-first strategy with an institutional multidisciplinary consensus, based on their hypothesis that the PORT-first strategy possibly being more effective in locoregional control than the PORT after POCT without compromising proven overall survival benefit of POCT.