Special Series

IMDT Corner

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The "IMDT Corner" features case report with International Multidisciplinary Team (iMDT) discussion, including the opinions of all relevant international health professionals discussing options and making joint decisions about treatment and supportive care plans, taking into account the personal preferences of the patient, to provide high quality, precision treatment options and management of the individual patient’s needs.

Meet the Professor

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The "Meet the Professor" series features interviews with the global Key Opinion Leaders, providing a window into the new developments, breakthroughs, and achievements in the interviewees’ professional fields, both clinically and academically.

Cough Section

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Cough is among the most common complaints for which patients worldwide seek medical attention. Acute cough, defined as cough of less than 3 weeks’ duration, is often transient and self-limited, although it may cause significant morbidity. Chronic cough (>8 weeks duration) often responds to targeted therapy once the underlying cause is defined but,

Grand Rounds

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The Grand Rounds (GR) is designed to become one of the most featured columns in our journal. Currently, GR articles at JTD replay the sessions where a typically intractable case was discussed among a panel of physicians, radiologists, pathologists, thoracic surgeons, oncologists and other healthcare professionals.

Clinical Management of Thoracic Traumas

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We put together in a single publication, all the major topics about the trauma of the chest, making possible for the readers to find review and easy-to-consult articles and updates on this.

Onco-Cardiology

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Cardio-oncology aims to identify cancer therapy-related cardiovascular side-effects and to provide optimum multidisciplinary care for cancer patients. We are in the process of gaining a profound knowledge on underlying pathomechanisms and clinical implications, but standardized recommendations and structural requirements for the treatment of cardio-oncology patients are still limited. In this edition of the Journal, experts in the field shield light on novel aspects and data for the diagnostic and therapy of cancer therapy—induced cardiovascular diseases. They critically review the literature and give recommendation for the daily practice.

Sleep Disordered Breathing and Cardiovascular Disease

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The growing evidence of independent association of obstructive sleep apnoea (OSA) with cardiovascular disease and the recent negative reports of benefit from nasal continuous positive airway pressure (CPAP) outcome studies justify a detailed exploration of the association of OSA with cardiovascular diseases and their outcomes, which provides the rationale for this special supplement in the Journal. The collection of papers covers the most important cardiovascular disorders associated with OSA and are written by internationally recognised experts on the respective topics.

Unmet in Transcatheter Aortic Valve Implantation

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Over the last 15 years, we have seen a rapid and exponential uptake of transcatheter aortic valve implantation (TAVI) for the treatment of patients with severe symptomatic aortic stenosis. This uptake has also been coupled with the evolution and advancement in transcatheter valve technologies.

Management of Database

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This special issue of the Journal of Thoracic Disease (JTD) represents the first collection of invited articles dealing with all the spectrum of databases in the field of thoracic surgery, organized under the of the umbrella of the European Society of Thoracic Surgery (ESTS).

Atrial Septal Defect

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This issue first focuses on the basic knowledge of ASDs, dealing with anatomical considerations, genetic basis and pathophysiology. We then explore the assessment modalities and considerations for planning a case in the operating room or in the catheterization laboratory. The third part is dedicated to ASD closure, going through imaging guidance, transcatheter techniques and surgical approach.

Lung Volume Reduction

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Emphysema treatment will remain subject to a multidisciplinary, but highly specialized team approach to find the individual appropriate therapy concept for each patient. The present special issue may assist the reader in finding the optimal approach. 

The 4th International Joint Meeting on Thoracic Surgery, Barcelona, 2018

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This Focused Issue features some of the invited presentations at the meeting and aims to review current evidence and management strategies, discuss the techniques of thoracic surgeries and the practical implications of the 8th edition of the tumour, node and metastasis (TNM) classification, as well as to give some insight into the future development or practice.

Advances in Radiation Oncology for Thoracic Malignancies

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 The issue covers advances in technology relevant to the practice of radiation oncology in the modern era, as well as the most current treatment approaches for early-stage, advanced, recurrent and oligometastatic non-small cell lung cancer (NSCLC), while recognizing the importance of tumor biology, radiation fractionation, immunotherapy, and functional imaging in the modern treatment of NSCLC.

Regenerative Medicine for Heart and Lung

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On the one hand, regenerative medicine applications are already a clinical reality in fields like orthopedics, dentistry and plastic surgery. On the other, their clinical benefits elsewhere, as in cardiac regeneration, remain unclear and highly debated.

Influenza and Other Respiratory Viruses

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The year 2018 is the centennial anniversary of the most devastating infectious disease of defined pathogen in recorded history: the 1918 influenza pandemic. In the past 100 years, human being has been suffering from continuous threats of influenza viruses.

Hong Kong Queen Mary Hospital Second Thoracic Surgery Symposium

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The wide breath of topics covered include Professor John Wong’s first-hand account of esophageal resection at the University of Hong Kong from 1982 to 2008, the first report of successful combined esophagectomy and carinal pneumonectomy, a rare and hard to diagnose condition—congenital H-type tracheoesophageal fistula…

Asia Thoracic Cancer Care Summit 2018 (Part II)

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The 2018 Asia Thoracic Cancer Care Summit (ATCCS) was held in Hong Kong from April 13–14, 2018. World-renowned experts in thoracic cancer management, shared their professional opinions on managing chest and lung cancers in the hope for future advancement and innovation.

Immunotherapy & Thoracic Cancers

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Topic chapters touch on the role of immunotherapy in MPM, SCLC, and thymic cancers with the discussion of the available guidelines to assist clinicians in their practice. The early diagnosis and the correct management of immune-related adverse events are also explored.

Focused on Enhanced Recovery Pathways in Thoracic Surgery

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In thoracic surgery, the benefits of ERAS are very well demonstrated. Shortenings of chest drain durations and lengths of stay are measured in days, complication rates are reduced to fractions of what they were, and assessments of patient functional recovery and satisfaction are significantly improved.

Sublobar Resections for Lung Cancer

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It is clear that current thinking on sublobar resections opens up an area of investigation for thoracic surgeons. This is reflected in this special issue of the JTD, which brings together many of the papers presented at the Paris conference

Dedicated to the 26th European Conference on General Thoracic Surgery (ESTS 2018)

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Topics include chest trauma and surgical chest wall stabilization; new concepts in immunosuppression for lung transplantation; the indications for use of extracorporeal life support in our specialty; the role of prehabilitation and rehabilitation for thoracic surgical patients; how to get the best from robotic thoracic surgery; and a report on international practice patterns from the ESTS-Venous Thromboembolism working group

Early Detection and Diagnosis of Lung Cancer

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In this issue, a comprehensive review of the detection and diagnosis of lung cancer is provided by expert investigators in the field focusing on all imaging techniques, but also incorporating liquid biopsy and complex next generation sequencing to capture very low frequency mutations and circulating DNA.

Asia Thoracic Cancer Care Summit 2018 (Part I)

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The management of thoracic disease is changing rapidly. As we continue to gain understanding of the pathophysiology and underlying molecular basis of these conditions, we are faced with more management options, including targeted therapy (its definition is also rapidly evolving), catheter-based treatments, minimally invasive surgery, and all forms of novel radiotherapy, just to mention a few.

Immunotherapy in Lung Cancer

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Strategies to modulate the body’s innate and adaptive immunity to treat advanced stage cancer has taken central stage in the management of solid and hematologic malignancies. Agents targeting the programmed death-1 (PD-1) pathway in particular, have become established therapies for various types of cancer.

Present and Future of the Malignant Pleural Mesothelioma

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Malignant pleural mesothelioma (MPM) is still considered a relatively rare tumour, although Europe is at the peak of an epidemic of malignant pleural mesothelioma and the burden of disease is likely to continue rising in the large areas of the world where asbestos remains unregulated. Patients with mesothelioma present with thoracic symptoms and radiological changes so respiratory physicians take a leading role in diagnosis and management.

GARD Section

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Column Editor: Yousser Mohammad, Alvaro A. Cruz

Global Alliance against Chronic Respiratory Diseases (GARD), a network of organizations led by WHO

ECG Pearls

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Surface 12-lead ECG remains in the 21st century, one of the diagnostic tools most extensively used in clinical practice. For the internist, the anaesthesiologist, the thoracic surgeon, the respirologist and the cardiologist, maintaining ECG interpretation skills is mandatory, as the ECG allows a rapid (and inexpensive) diagnosis of a large series of entities. The advances of new technologies have not replaced the ECG, which still is one of the most cost/effective tools in medicine. Several interventions (in the acute and chronic phases of a disease) are still guided by the proper analysis of the surface ECG.

Quantitative Imaging of Thoracic Diseases

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Column Editor: Yì Xiáng J. Wáng, Jiang Lin

The importance of quantitative imaging has been increasingly recognized both in clinical and research settings, motivated particularly by the growing need for individualized precision medicine. This focused issue of Journal of Thoracic Diseasehighlights current topics in the field of quantitative imaging addressing many common yet in the meantime debilitating diseases in the chest.

Dedicated to the 27th International Congress of the European Respiratory Society (ERS 2017)

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The ERS International Congress is one of the biggest annual events in the respiratory calendar—bringing over 20,000 respiratory professionals together for the latest scientific knowledge and hot topics in respiratory medicine.

Our Congress is an inclusive event; the programme has something for everyone, whether you are a clinician, a scientist or allied health professional, whether you are in the early stages of your career or a professional with many years’ experience.

Thoracic (Lung & Thymic) Neuroendocrine Tumors

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The improvement in awareness, the recent radiological techniques advancement, and the accumulating experience on diagnosis of small, peripheral pulmonary nodules (especially through the lung cancer screening programs, which was dramatically increased worldwide), along with the tremendous diffusion of immunohistochemistry in the pathological diagnosis of lung neoplasms, made a sensible growing of thoracic neuroendocrine tumor (TNT) diagnosis possible, in the last decades. The interest to TNTs management has never been so strong as in the last few years. Several articles concerning biology, associated paraneoplastic syndromes, surgery, imaging, follow-up schedule, new drugs available both in induction and/or in adjuvant setting, have been recently published.

The Evolving Concept of Liquid Biopsy in Non-Small Cell Lung Cancer Patients

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As an integral part of precision medicine, the role of liquid biopsy in non-small cell lung cancer (NSCLC) is highlighted in this special issue of Journal of Thoracic Disease with a selection of articles written by a panel of eminent experts. There are many reasons to consider NSCLC as a potential ideal field of application for liquid biopsy: first, the availability of a non-invasive and repeatable method for diagnosis and disease monitoring could be extremely useful in NSCLC patients, considering that physicians have difficulty in obtaining an adequate tumor tissue with standard procedures and that patients are not always suitable to receive a re-biopsy; second, analysis of circulating tumor cells (CTCs) or circulating tumor DNA (ctDNA) which originate from all potential lesions could overcome the disadvantages of single site biopsy; last but not least, recent stuxdies showed either that CTCs count may have a prognostic value in NSCLC or that molecular characterization of CTCs/ctDNA may permit the assessment of druggable alterations.

Pulmonary Metastasectomy

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Pulmonary metastasectomy is one of the most common procedures undertaken by thoracic surgery departments worldwide. It is performed to treat lung metastases from primary malignancies with the goal of radically resecting all lung metastases disclosed by preoperative staging CT scan and by intraoperative manual palpation.

Focused on Lung Cancer Precision Medicine

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Cancer medicine has evolved in recent years thanks to advances in cancer biology, allowing many dedicated scientists and medical oncologists to thoroughly investigate the inner core of cancer cells. The initiative of JTD to gather some of the most prominent Chinese researchers in the field of lung cancer is certainly inspiring for members of the scientific community, especially those dedicated to lung cancer. The selection of Chinese scholars is not arbitrary since all epitomize the main virtues of researchers: full motivation, curiosity, determination and ceaseless work. The readers will find a cornucopia of information on the successes of different Chinese careers and an immense fountain of information and inspiration. Certainly, such salient investigators’ interviews provide a spearhead for further investigators in the complex field of cancer.

Interventional Pulmonology

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We are pleased to announce this focused issue of the Journal of Thoracic Disease on “interventional pulmonology”. Thoracic procedures are better tolerated when they are minimally invasive, leading to shorter hospital stays, fewer complications, and possibly lower costs.

ICC Column: The Voice of the Patient

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Past Column Editor: Lawrence Grouse

What is the core value of clinical service and medical research? It follows the most important rule that “patients come first.” And what on earth drives our aim and scope at Journal of Thoracic Disease (JTD)? It is the passion for patient benefits. In August 2012, JTD was endorsed by and has been collaborating with the International COPD Coalition (ICC) ever since. JTD’s ICC column is jointly elaborated by JTD and ICC as a regular column with the global efforts of COPD patient organizations, lung physicians and experts dealing with the global COPD epidemic. ICC column aims at exploring the protection of patients’ rights in clinical diagnosis and treatment through introducing the endeavor and achievement made internationally for COPD patient benefits. It concerns social issues with wide topics including the patients’ rights protection, reducing patients’ health care expenses, medical bribery, and the relationship between pharmaceutical industry development and patients’ rights, to name a few.

Evidenced-Based Clinical Problem Solving Article

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Column Editor: Zhongheng Zhang

Evidenced-Based Clinical Problem Solving is an approach to patient care that involves considering the best available research and practice guidelines associated with a specific clinical situation. The column of Evidenced-based clinical problem solving in JTD aims to provide a platform for the communication between researchers and clinicians.

Interventional Pulmonology Corner (IP Corner)

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Column Editor: Kassem Harris

The goal of this Interventional Pulmonology Corner (IP Corner) is to continuously provide the readers with most updated evidence and knowledge on interventional pulmonology. The IP Corner is dedicated to publishing articles related to minimally invasive thoracic procedures. This most particularly involves topics related to diagnostic and therapeutic bronchoscopy, pleural procedures, and percutaneous tracheostomy.

Statistics Corner

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Column Editor: Luca Bertolaccini

The goal of the special section on Statistic Corner in the Journal of Thoracic Disease is to en able readers to confront which statistical method to apply and when by conveying statistic al knowledge in the general strategies for the statistical analysis. Biostatistics is a growing topic of a continuous development of new techniques and the understanding of it is import ant to all Thoracic Surgeons, but what Thoracic Surgeons need is to take small doses of Bio statistics, ready to use, and absorbable in a few minutes. This is mainly why the readers of the Journal of Thoracic Disease may ask the Editors a Statistics Corner.

Bioresorbable Vascular Scaffolds for the Treatment of Coronary Artery Disease

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This focused issue provides the reader with a “state-of-art” vision of the BRS technology (and the related clinical results) as it stands in 2017. It begins with an original overview of Italian Interventional Cardiologists regarding past, present and future of BRS technology. Then, it develops important topics such as BRS clinical performance in different settings (i.e., acute coronary syndromes, small vessels, diabetic patients), the role of intracoronary imaging in guiding BRS implantation, the mechanical behavior of polymeric and metallic BRS. In addition, the limitations of current BRS and their possible solution are summarized. Finally, the issue opens to the future with an update on new BRS platforms and their early clinical results.

Esophageal Cancer

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This issue covers subjects about surgical anatomy, the proper anaesthesia during the intervention, diagnostic aspects, the selection of patients for neoadjuvant therapy, the best neoadjuvant therapy, the extension of mediastinal lymphadenectomy, the proper surgical treatment for squamous cell cancer and adenocarcinomas, as well as esophagogastric junctional tumors, the issue of the adequate checklist and fast track modalities, and the issue when to start with feeding of patients after operation. 

Innovations in the management of valvular and structural heart disease

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Over the last decade, there has been a fervent interest in less invasive approaches to valvular and structural interventions. In the current supplement issue of the Journal of Thoracic Disease, contributing authors present original research and meta-analytic studies, review articles, and editorials regarding these innovative techniques in the field of valvular and structural heart disease. 

Aortic Diseases

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In this issue, we report, talk and discuss on the need to unify criteria for image techniques, the last guidelines on aortic diseases, the need of new predictive models for mortality after aortic surgery, surgical and image techniques challenges, reoperations, the role of medical treatment on these diseases, we show sparing aortic root repairs. We even talk about the problem of health care cost control in Spain and other European countries where there is public and free Health System or the birth of the Star Chamber, an ingenious idea to prevent surgeons from running away from high-risk interventions

EBUS-TBNA: Results and Perspective

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The aim of the International Workshop “EBUS-TBNA for Lung Cancer Diagnosis and Staging—State of the Art”, held in Varese in October 2016, was to present and compare results from national and international experts on this topic. Different issues have been analysed and discussed, including the points of view of pathologist, oncologist, chest physician, and surgeon. Finally, the EBUS-TBNA perspective has been explored through an active and useful discussion among the panellists. These topics have been summarised in this supplement of the Journal of Thoracic Disease with the aim to provide a recent update.

New Imaging and Diagnostic Modalities in Cardiac Surgery

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New therapies are now available for old diseases as in the case of the trans-catheter interventions for aortic stenosis or functional mitral regurgitation. These therapies are made possible by new and highly sophisticated imaging techniques and require the cooperation of specialists of different medical backgrounds (cardiologists, cardiac surgeons, radiologists, anesthesiologists) in an integrated setting. This monographic issue of Journal of Thoracic Disease was conceived to facilitate this new collaboration. In the volume, experts in various imaging modalities (CT, echocardiography, MRI, nuclear medicine) as well as cardiologists, intensivists and cardiac surgeons provide the state of the art expertise of the distinctive imaging techniques used in the cardiovascular field with the aim of facilitating a universal language and the sharing of knowledge



Dedicated to the 25th European Conference on General Thoracic Surgery (ESTS 2017)

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Topics in this focused issue include chest trauma and surgical chest wall stabilization; salvage surgery after definitive radiotherapy; the role of sublobar resections for early stage lung cancer; management of multifocal ground glass opacities of the lung in the era of lung cancer screening; thoracic sympathectomy for hyperhidrosis; the perspective of a trainee regarding the thoracic surgery training in Europe; and the role of CXC group chemokines in lung cancer development and progression. This issue is once again dedicated to all women and men working in the field of thoracic surgery, surgeons, nurses, physiotherapists and allied health professionals who, with their daily commitment and passion help advance our specialty and assure our patients a high quality of care, a better quality of life and an improved long-term survival


Advances in Bronchoscopic and Endoscopic Interventions for Thoracic Disease

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The diagnosis and treatment of thoracic malignancies continues to evolve. It is imperative that the thoracic surgeons evolve in tandem with these advances, and that our trainees similarly are exposed to new ways of managing thoracic disease. The solution is to understand which new modalities and interventions are available for maintaining a complete, full-service thoracic practice, to optimize care of our patients