The improvement in awareness, the recent radiological techniques advancement, and the accumulating experience on diagnosis of small, peripheral pulmonary nodules (especially through the lung cancer screening programs, which was dramatically increased worldwide), along with the tremendous diffusion of immunohistochemistry in the pathological diagnosis of lung neoplasms, made a sensible growing of thoracic neuroendocrine tumor (TNT) diagnosis possible, in the last decades. The interest to TNTs management has never been so strong as in the last few years. Several articles concerning biology, associated paraneoplastic syndromes, surgery, imaging, follow-up schedule, new drugs available both in induction and/or in adjuvant setting, have been recently published.
