This focused issue provides the reader with a “state-of-art” vision of the BRS technology (and the related clinical results) as it stands in 2017. It begins with an original overview of Italian Interventional Cardiologists regarding past, present and future of BRS technology. Then, it develops important topics such as BRS clinical performance in different settings (i.e., acute coronary syndromes, small vessels, diabetic patients), the role of intracoronary imaging in guiding BRS implantation, the mechanical behavior of polymeric and metallic BRS. In addition, the limitations of current BRS and their possible solution are summarized. Finally, the issue opens to the future with an update on new BRS platforms and their early clinical results.