@article{JTD12445,
author = {Guang-Zong Chen and Hong-Cheng Zhu and Wang-Shu Dai and Xiao-Ning Zeng and Jin-Hua Luo and Xin-Chen Sun},
title = {The mechanisms of radioresistance in esophageal squamous cell carcinoma and current strategies in radiosensitivity},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {3},
year = {2017},
keywords = {},
abstract = {Esophageal cancer is the eighth most common cancer and the sixth leading cause of cancer-related death worldwide. Surgery is the primary form of treatment, but the survival is poor, especially for patients with locally advanced esophageal cancer. Radiotherapy has been a critical treatment option that may be combined with chemotherapy in patients with unresectable esophageal cancer. However, resistance to chemoradiotherapy might result in treatment failures and cancer relapse. This review will mainly focus on the possible cellular mechanisms and tumor-associated microenvironmental (TAM) factors that result in radioresistance in patients with esophageal cancer. In addition, current strategies to increase radiosensitivity, including targeted therapy and the use of radiosensitive biomarkers in clinical treatment, are discussed in this review.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/12445}
}