TY - JOUR AU - Zhang, Shanyuan AU - Li, Shaolei AU - Pei, Yuquan AU - Huang, Miao AU - Lu, Fangliang AU - Zheng, Qingfeng AU - Li, Nan AU - Yang, Yue PY - 2017 TI - Impact of maximum standardized uptake value of non-small cell lung cancer on detecting lymph node involvement in potential stereotactic body radiotherapy candidates JF - Journal of Thoracic Disease; Vol 9, No 4 (April 25, 2017): Journal of Thoracic Disease Y2 - 2017 KW - N2 - Background: The retrospective study investigated the association between the maximum standardized uptake value (SUV max ) of primary tumor and lymph node involvement in potential stereotactic body radiotherapy (SBRT) candidates. Methods: A total of 185 patients with clinical stage I NSCLC were enrolled in the current study. All patients underwent lobectomy with systematic lymph node dissection following preoperative FDG-PET/CT scanning. The association between clinicopathological variables and lymph node involvement was analyzed by univariate and multivariate analysis. Spearman’s correlation test was used to evaluate the correlation between them. Receiver operating characteristic (ROC) analysis was performed to calculate the area under the curve. Results: Among these patients, 22.1% had occult lymph node involvement, 15.1% were N1 and 7.0% were N2. Greater tumor size (P=0.007), elevated CEA (P=0.006), central location (P=0.002), higher SUV max (P max (increase of 1 unite, OR 1.147, 95% CI: 1.035–1.272, P=0.009) and visceral pleural invasion (OR 3.044, 95% CI: 1.369–6.769, P=0.006). ROC area under the curve of SUV max for lymph node involvement was 0.770 (95% CI: 0.698–0.841), the sensitivity and specificity were 85.4% and 63.2%, respectively. Spearman’s correlation test showed that SUV max of tumor mostly depended on tumor size and nodule type. Conclusions: SUV max of primary tumor was a predictor of lymph node involvement for potential SBRT candidates. Centrally located tumor and visceral pleural invasion were related to higher rate of nodal metastasis. Lobectomy and systemic lymph node dissection should be performed in these patients, instead of SBRT. UR - https://jtd.amegroups.org/article/view/12759