%0 Journal Article %T RASSF1A methylation, YAP1 activation and metastasis: a new role for an old foe in lung cancer %A Oh, Min Hee %A Lockwood, William W. %J Journal of Thoracic Disease %D 2017 %B 2017 %9 %! RASSF1A methylation, YAP1 activation and metastasis: a new role for an old foe in lung cancer %K %X The majority of lung cancer patients die not from primary, but metastatic disease. While mutations/rearrangements in oncogenes such as KRAS, EGFR and ALK , occur early in tumorigenesis, experimental evidence suggests that additional alterations are required to promote tumor invasion and progression (1). Despite knowing a great deal about the molecular pathways associated with the metastatic phenotype, little is known about how these factors become deregulated to drive the spread of lung cancer cells. %U https://jtd.amegroups.org/article/view/13281 %V 9 %N 5 %P 1165-1167 %@ 2077-6624