TY - JOUR AU - Vavougios, Georgios D. AU - Zarogiannis, Sotirios G. PY - 2017 TI - MYCing and YAPing the escape of tumor cell growth arrest after chronic PI3K/mTOR inhibition JF - Journal of Thoracic Disease; Vol 9, No 5 (May 28, 2017): Journal of Thoracic Disease Y2 - 2017 KW - N2 - The phosphatidylinositol-3-kinase (PI3K)/Akt and mammalian target of rapamycin (mTOR) signaling cascades represent two critical and highly interconnected pathways regulating cellular proliferation, metabolism, differentiation and survival—particularly in response to cytotoxic stress (1). As a single pathway exploited by multiple neoplasms, mutations of PI3K/mTOR’s components represent attractive pharmacological targets, leading to the development of a wide array of targeted therapies (2). UR - https://jtd.amegroups.org/article/view/13404