@article{JTD13560,
author = {Nicola Rotolo and Andrea Imperatori and Mario Nosotti and Luigi Santambrogio and Alessandro Palleschi and Lorenzo Dominioni and Giorgio Crosta and Pierfranco Foccoli and Gianluca Pariscenti and Eliseo Passera and Luigi Bortolotti and Giovanni Falezza and Maurizio Infante and Elisa Daffrè and Maria Cattoni and Lorenzo Rosso},
title = {Multicentric study of endobronchial ultrasound-transbronchial needle aspiration for lung cancer staging in Italy},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {Suppl 5},
year = {2017},
keywords = {},
abstract = {Background: Multi-institutional studies of endobronchial-ultrasound transbronchial needle aspiration (EBUS-TBNA) for mediastinal staging in lung cancer are scarce. It is unclear if the high diagnostic performance of EBUS-TBNA reported by experts’ guidelines can be generally achieved.
Methods: This is a retrospective study performed in five tertiary referral centers of thoracic surgery in Italy, to assess the EBUS-TBNA diagnostic performance in patients with non-small cell lung cancer (NSCLC). Patient inclusion criteria were: both genders; >18 years old; with suspect/confirmed NSCLC; undergoing EBUS-TBNA for mediastinal node enlargement at computed tomography (size >1 cm, ≤3 cm) and/or pathological uptake at positron emission tomography. Altogether we included 485 patients [male, 366; female, 119; median age, 68 years (IQR, 61–74 years)] undergoing mediastinal staging between January 2011 and July 2016. All EBUS-TBNAs were performed by experienced bronchoscopists, without pre-defined quality standards. Depending on usual practice in each center, EBUS-TBNA was done under conscious sedation, with 21- or 22-Gauge (G) needle, and specimen preparation was cell-block, or cytology slides, or core-tissue. Sampling was classified inadequate in absence of lymphocytes, or when sample was insufficient. We analyzed the EBUS-TBNA procedural steps likely to influence the rate of adequate samplings (diagnostic yield).
Results: EBUS-TBNA sensitivity, negative predictive value (NPV) and accuracy respectively were 90%, 78% and 93% in the whole cohort. At multivariate analysis, use of 21-G needle was associated with better diagnostic yield (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/13560}
}