@article{JTD14525,
author = {Surya Say Biere and Mark I. van Berge Henegouwen and Luigi Bonavina and Camiel Rosman and Josep Roig Garcia and Suzanne S. Gisbertz and Donald L. van der Peet and Miguel A. Cuesta},
title = {Predictive factors for post-operative respiratory infections after esophagectomy for esophageal cancer: outcome of randomized trial},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {Suppl 8},
year = {2017},
keywords = {},
abstract = {Background: The first and only randomized trial comparing open esophagectomy (OE) with minimally invasive esophagectomy (MIE) showed a significant lower incidence of post-operative respiratory infections in the patients who underwent MIE. In order to identify which specific factors are related to a better respiratory outcome in this trial an additional analysis was performed.
Methods: This was a prospective, multicenter, randomized controlled trial. Eligible patients, with a resectable intrathoracic esophageal carcinoma, including the gastro-esophageal (GE) junction tumors and Eastern Cooperative Oncology Group ≤2, were randomized to either MIE or OE. Respiratory infection investigated was defined as a clinical manifestation of (broncho-) pneumonia confirmed by thorax X-ray and/ or Computed Tomography scan and a positive sputum culture. A logistic regression model was used.
Results: From 2009 to 2011, 115 patients were randomized in 5 centers. Eight patients developed metastasis during neoadjuvant therapy or had an irresectable tumor and were therefore excluded from the analysis. Fifty-two OE patients were comparable to 55 MIE patients with regard to baseline characteristics. In-hospital mortality was not significantly different [2% (open group) and 4% (MIE group)]. A body mass index (BMI) ≥26 and OE were associated with a roughly threefold risk of developing a respiratory infection.
Conclusions: Overweight patients and OE are independently associated with a significant higher incidence of post-operative respiratory infections, i.e., pneumonia.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/14525}
}