TY - JOUR AU - Dong, Zhengwei AU - Zhou, Hui Li, Jun AU - Zhang, Wei AU - Wu, Chunyan PY - 2017 TI - The value of cell block based on fine needle aspiration for lung cancer diagnosis JF - Journal of Thoracic Disease; Vol 9, No 8 (August 28, 2017): Journal of Thoracic Disease Y2 - 2017 KW - N2 - Background: Computed tomography (CT)-guided percutaneous lung fine needle aspiration (FNA) is a convenient method to obtain samples from pulmonary lesions. FNA has a lower rate of complications than the use of a core needle biopsy, but is more difficult for the diagnosis of cytological samples. We use cell block (CB) and immunocytochemistry (ICC) to improve the accuracy of cytological diagnoses based on CT-guided percutaneous lung FNA. Methods: We collected 526 cytological samples obtained using CT-guided percutaneous lung FNA at Shanghai Pulmonary Hospital from May 2015 to October 2015. CBs were created from these samples, and ICC was performed to help the further histological classification and confirmation of tumor as primary or metastatic. An automated Ventana ALK with clone D5F3 was used to identify ALK fusion protein. Results: After assessment of the CBs, 32 (6.08%) diagnoses of suspected malignancy were reduced to 10 (1.90%) such diagnoses (P ALK rearrangement. Conclusions: CB and ICC are useful for accurate cytological diagnosis using CT-guided percutaneous lung FNA. These approaches are valuable for providing individualized treatment and prognostic evaluations with minor complications. UR - https://jtd.amegroups.org/article/view/14884