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Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids

  
@article{JTD15033,
	author = {Masaya Takemura and Masayuki Nishio and Kensuke Fukumitsu and Norihisa Takeda and Hiroya Ichikawa and Takamitsu Asano and Hiroki Tomita and Yoshihiro Kanemitsu and Kosho Yoshikawa and Akio Niimi},
	title = {Optimal cut-off value and clinical usefulness of the Adherence Starts with Knowledge-12 in patients with asthma taking inhaled corticosteroids},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {8},
	year = {2017},
	keywords = {},
	abstract = {Background: Non-adherence to inhalation regimens is common in asthmatic patients. The Adherence Starts with Knowledge-12 (ASK-12) survey was developed to detect and address patient-specific barriers to medication adherence. Our objective is to investigate the clinical usefulness of the ASK-12 for assessing and addressing adherence to inhalation therapy in asthma.
Methods: The ASK-12 was administered to 138 asthmatic patients. Using pharmacy-refill data, we examined the cut-off value of the ASK-12 to identify patients who were non-adherent to inhalation regimens and identify factors associated with non-adherence. To verify the usefulness of the ASK-12, inhalation regimens were prospectively switched to less-expensive and simpler (once-daily) dosing regimens in eight non-adherent asthmatic patients who reported specific-barriers in “inconvenience of twice-daily inhaler use” and “cost”.
Results: Valid responses were received from 114 (82.6%) patients. A significant correlation was found between pharmacy-refill rates and the ASK-12 total score (r=−0.55, P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/15033}
}