TY - JOUR AU - Patel, Akash M. AU - Berger, Ian AU - Wileyto, E. Paul AU - Khalid, Urooj AU - Torigian, Drew A. AU - Nachiappan, Arun C. AU - Barbosa Jr, Eduardo M. AU - Gefter, Warren B. AU - Galperin-Aizenberg, Maya AU - Gupta, Narainder K. AU - Simone II, Charles B. AU - Haas, Andrew R. AU - Alley, Evan W. AU - Singhal, Sunil AU - Cengel, Keith A. AU - Katz, Sharyn I. PY - 2017 TI - The value of delayed phase enhanced imaging in malignant pleural mesothelioma JF - Journal of Thoracic Disease; Vol 9, No 8 (August 28, 2017): Journal of Thoracic Disease Y2 - 2017 KW - N2 - Background: Cross-sectional imaging of malignant pleural mesothelioma (MPM) can underestimate the presence of local tumor invasion. Since accurate staging is vital optimal choice of therapy, techniques that optimize pleural imaging are needed. Here we estimate the optimal timing of MPM enhancement on magnetic resonance imaging (MRI). Methods: All MPM patients with intravenous (IV) contrast enhanced staging MRI between 2000–2016 at our institution were retrospectively selected for image analysis. Patients with incomplete imaging protocol and maximum pleural tumor thickness Results: Of the 42 MPM patients who had undergone staging MRI during the study period, 12 patients met the study criteria. Peak tumor enhancement was between 150 and 300 sec following IV contrast administration. Within this time window, 80% of patients are projected to have reached >80%, >85%, and >90% peak tumor enhancement. There was a statistically significant correlation between increasing tumor enhancement and subjective lesion conspicuity. Conclusions: Optimal MPM enhancement on MRI likely occurs at a time delay between 2.5–5 min following IV contrast administration. Further study of delayed phase enhancement of MPM with dynamic contrast enhanced MRI is warranted. UR - https://jtd.amegroups.org/article/view/15043