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Esophageal resection after neoadjuvant therapy: understanding the limitations of large database analyses

  
@article{JTD15730,
	author = {David N. Ranney and Michael S. Mulvihill and Babatunde A. Yerokun and Matthew G. Hartwig},
	title = {Esophageal resection after neoadjuvant therapy: understanding the limitations of large database analyses},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {10},
	year = {2017},
	keywords = {},
	abstract = {Determining the optimal timing of surgical resection for esophageal adenocarcinoma following neoadjuvant therapy has proven to be a challenging task, and the clinical implications for patients undergoing surgery at various time intervals remain elusive. In an effort to fill a gap in the current retrospective literature pertaining to this clinical question, we utilized the method of restricted cubic splines (RCS) to investigate the balance in this timing from a unique statistical perspective. Using the National Cancer Database (NCDB), we determined an inflection point of 56 days wherein an increased incidence of pathologic complete response was balanced with a decreased rate of overall survival (1).},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/15730}
}