%0 Journal Article %T Esophageal resection after neoadjuvant therapy: understanding the limitations of large database analyses %A Ranney, David N. %A Mulvihill, Michael S. %A Yerokun, Babatunde A. %A Hartwig, Matthew G. %J Journal of Thoracic Disease %D 2017 %B 2017 %9 %! Esophageal resection after neoadjuvant therapy: understanding the limitations of large database analyses %K %X Determining the optimal timing of surgical resection for esophageal adenocarcinoma following neoadjuvant therapy has proven to be a challenging task, and the clinical implications for patients undergoing surgery at various time intervals remain elusive. In an effort to fill a gap in the current retrospective literature pertaining to this clinical question, we utilized the method of restricted cubic splines (RCS) to investigate the balance in this timing from a unique statistical perspective. Using the National Cancer Database (NCDB), we determined an inflection point of 56 days wherein an increased incidence of pathologic complete response was balanced with a decreased rate of overall survival (1). %U https://jtd.amegroups.org/article/view/15730 %V 9 %N 10 %P E949-E950 %@ 2077-6624