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Physiological rules for the heart, lungs and other pressure-based organs

	author = {Aaron R. Casha and Liberato Camilleri and Alexander Manché and Ruben Gatt and Marilyn Gauci and Marie-Therese Camilleri-Podesta and Joseph N. Grima and Marco Scarci and Stanley Chetcuti},
	title = {Physiological rules for the heart, lungs and other pressure-based organs},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {10},
	year = {2017},
	keywords = {},
	abstract = {Background: The adherence of the heart to physical laws, such as Laplace’s Law, may act as a measure of the organ’s relative efficiency. Allometric relationships were investigated to assess the heart’s efficiency concerning end-diastolic and end-systolic volumes, cardiac pressurization energy, cardiac output and mass. 
Methods: Data to generate allometric relationships was obtained using a literature search, identifying heart and lung data across different mammalian and bird species. Statistical analysis was carried out using ordinary least squares (OLS) estimation. 
Results: Near isometric relationships exist between body mass and seven parameters indicating no “efficiency of size” with scaling of the heart, and size-matching of the heart to the lungs and whole body. Even though there was equal efficiency in pressurization energy generation, cardiac output was maximally efficient in small mammals },
	issn = {2077-6624},	url = {}