How to cite item

No compensatory lung growth after resection in a one-year follow-up cohort of patients with lung cancer

	author = {Stéphane Glénet and Claire de Bisschop and Frédéric Delcambre and Rodolphe Thiébaut and François Laurent and Jacques Jougon and Jean-François Velly and Agnès Georges and Hervé Guénard},
	title = {No compensatory lung growth after resection in a one-year follow-up cohort of patients with lung cancer},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {10},
	year = {2017},
	keywords = {},
	abstract = {Background: As compensatory lung growth after lung resection has been studied in animals of various ages and in one case report in a young adult, it has not been studied in a cohort of adults operated for lung cancer.
Methods: A prospective study including patients with lung cancer was conducted over two years. Parenchymal mass was calculated using computed tomography before (M0) and at 3 and 12 months (M3 and M12) after surgery. Respiratory function was estimated by plethysmography and CO/NO lung transfer (DLCO and DLNO). Pulmonary capillary blood volume (Vc) and membrane conductance for CO (DmCO) were calculated. Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) plasma concentrations were measured simultaneously. 
Results: Forty-nine patients underwent a pneumonectomy (N=12) or a lobectomy (N=37) thirty two completed the protocol. Among all patients, from M3 to M12 the masses of the operated lungs (239±58 to 238±72 g in the lobectomy group) and of the non-operated lungs (393±84 to 377±68 g) did not change. Adjusted by the alveolar volume (VA), DLNO/VA decreased transiently by 7% at M3, returning towards the M0 value at M12. Both Vc and DmCO increased slightly between M3 and M12. IGF-1 and IGFBP-3 concentrations did not change at M3, IGF-1 decreased significantly from M3 to M12. 
Conclusions: Compensatory lung growth did not occur over one year after lung surgery. The lung function data could suggest a slight recruitment or distension of capillaries owing to the likely hemodynamic alterations. An angiogenesis process is unlikely.},
	issn = {2077-6624},	url = {}