TY - JOUR AU - Bertoglio, Pietro AU - Aprile, Vittorio AU - Ambrogi, Marcello Carlo AU - Mussi, Alfredo AU - Lucchi, Marco PY - 2017 TI - The role of intracavitary therapies in the treatment of malignant pleural mesothelioma JF - Journal of Thoracic Disease; Vol 10, Supplement 2 (January 30, 2018): Journal of Thoracic Disease (Present and Future of the Malignant Pleural Mesothelioma) Y2 - 2017 KW - N2 - Surgery is one of the steps of multimodality approach for the treatment of MPM. Due to anatomical features, microscopically radical (R0) resection is never possible and a Macroscopic Complete Resection (R1) is considered the target for mesothelioma surgeons. Recently, intracavitary therapies have been described with the aim of extending the loco-regional effect of surgery. Different agents might be administered intrapleurally: chemotherapy drugs are the most widely used, but also photodynamic therapy (PDT) showed to lead to satisfactory long-term outcomes; furthermore, immunotherapies and gene therapies have been also reported. Despite promising results, no high-quality evidences are currently available and controlled randomized trials are required to establish the exact role of intracavitary therapies and to standardize the technique. UR - https://jtd.amegroups.org/article/view/16989