TY - JOUR AU - Petrini, Iacopo AU - Lucchesi, Maurizio AU - Puppo, Gianfranco AU - Chella, Antonio PY - 2017 TI - Medical treatment of malignant pleural mesothelioma relapses JF - Journal of Thoracic Disease; Vol 10, Supplement 2 (January 30, 2018): Journal of Thoracic Disease (Present and Future of the Malignant Pleural Mesothelioma) Y2 - 2017 KW - N2 - Abstract: There are not established treatments for patients with advanced malignant pleural mesothelioma that progressed after first-line chemotherapy with cisplatin and pemetrexed. Retrospective analyses suggest a possible role for rechallenge with pemetrexed for selected patients. Phase II trials demonstrate a modest efficacy of vinorelbine monotherapy with a response rate ranging between 0% and 18% and a tolerable toxicity profile. Combination schedules, despite an increased toxicity, fail to demonstrate an improved efficacy. To date, genome wide analyses did not show molecular targets suitable for therapy and biological drugs did not exert a significant efficacy in clinical trials. Immunotherapy has given a hint of efficacy in early clinical trials but definitive evaluations are still ongoing. UR - https://jtd.amegroups.org/article/view/17364