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Is a 5-mm diameter an appropriate cut-off value for the diagnosis of atypical adenomatous hyperplasia and adenocarcinoma in situ on chest computed tomography and pathological examination?

  
@article{JTD18247,
	author = {Xiaohuan Pan and Xinguan Yang and Jingxu Li and Xiao Dong and Jianxing He and Yubao Guan},
	title = {Is a 5-mm diameter an appropriate cut-off value for the diagnosis of atypical adenomatous hyperplasia and adenocarcinoma in situ on chest computed tomography and pathological examination?},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {7},
	year = {2018},
	keywords = {},
	abstract = {Background: Preinvasive lesions, such as atypical adenomatous hyperplasia (AAH) and adenocarcinoma in situ (AIS), usually appear as pure ground-glass nodules (pGGNs) on thin-section computed tomography (TSCT). AAH is usually less than 5 mm wide on imaging and pathological examinations. We aimed to determine whether a 5-mm cut-off value was appropriate for the diagnosis of AAH and AIS.
Methods: We retrospectively analyzed the performance of TSCT in evaluating 80 pathologically con rmed preinvasive lesions (33 AAH lesions in 31 patients and 47 AIS lesions in 45 patients). We compared the following characteristics between the AAH and AIS groups: lesion diameter, density, rim, lobulation, spiculation, vacuole sign, aerated bronchus sign, pleural indentation sign, and pathological  ndings. 
Results: All 80 lesions appeared as pGGNs. On TSCT, the average diameter of AAH lesions (6.0±1.64 mm) was significantly smaller than that of AIS lesions (8.7±3.16 mm; P},
	issn = {2077-6624},	url = {http://jtd.amegroups.com/article/view/18247}
}