@article{JTD18433,
author = {Chang-Hao Zhong and Da Tong and Zi-Qing Zhou and Zhu-Quan Su and Yu-Long Luo and Jia Xing and Ya-Li Bai and Su- Jie Guo and Shi-Yue Li},
title = {Performance evaluation of detecting circulating tumor cells and tumor cells in bronchoalveolar lavage fluid in diagnosis of peripheral lung cancer},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {Suppl 7},
year = {2018},
keywords = {},
abstract = {Background: To evaluate the diagnostic performances of detecting circulating tumor cells (CTCs) and tumor cells in bronchoalveolar lavage fluid (BALF) for peripheral lung cancer.
Methods: A total of 247 patients with lung cancer and 70 cases with benign lung disease were recruited in this study. Peripheral blood and BALF samples were collected, in which the tumor cells were enriched by negative immunomagnetic selection and detected by fluorescence in situ hybridization (FISH) of chromosome enumeration probe 8 (CEP8). The levels of tumor-associated markers (e.g., CEA, CA125, and NSE) in peripheral blood plasma were measured by using electrochemiluminescence.
Results: The numbers of CTCs detected in peripheral blood were significantly higher in patients with lung cancer than those with benign lung disease (5.78±0.57 vs. 1.13±0.39, Z=−8.64, P0.05) in discriminating benign lesions from lung cancer (sensitivity 83.8% and 92.6%, specificity 86.5% and 99.9%, respectively), both of which were larger than those of NSE, CEA, and CA125 (AUC =0.564, 0.512 and 0.554, respectively; all P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/18433}
}