%0 Journal Article %T Screen-detected multiple primary lung cancers in the ITALUNG trial %A Mascalchi, Mario %A Comin, Camilla E. %A Bertelli, Elena %A Sali, Lapo %A Maddau, Cristina %A Zuccherelli, Stefania %A Picozzi, Giulia %A Carrozzi, Laura %A Grazzini, Michela %A Fontanini, Gabriella %A Voltolini, Luca %A Vella, Alessandra %A Castiglione, Francesca %A Carozzi, Francesca %A Paci, Eugenio %A Zompatori, Maurizio %A Pegna, Andrea Lopes %A Falaschi, Fabio %A Research Group, for the ITALUNG Study %J Journal of Thoracic Disease %D 2018 %B 2018 %9 %! Screen-detected multiple primary lung cancers in the ITALUNG trial %K %X Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer. %U https://jtd.amegroups.org/article/view/18980 %V 10 %N 2 %P 1058-1066 %@ 2077-6624