TY - JOUR AU - Gea, Joaquim AU - Sancho-Muñoz, Antoni AU - Chalela, Roberto PY - 2018 TI - Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations JF - Journal of Thoracic Disease; Vol 10, Supplement 12 (May 26, 2018): Journal of Thoracic Disease (Nutritional Status and Muscle Dysfunction in Chronic Respiratory Disease: Stable Versus Acute Exacerbations) Y2 - 2018 KW - N2 - Nutritional abnormalities are frequent in different chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), interstitial fibrosis and lung cancer, having important clinical consequences. However, nutritional abnormalities often remained underdiagnosed due to the relative lack of awareness of health professionals. Therefore, systematic anthropometry or even better, assessment of body composition, should be performed in all patients with chronic respiratory conditions, especially following exacerbation periods when malnutrition becomes more accentuated. Nutritional abnormalities very often include the loss of muscle mass, which is an important factor for the occurrence of muscle dysfunction. The latter can be easily detected with the specific assessment of muscle strength and endurance, and also negatively influences patients’ quality of life and prognosis. Both nutritional abnormalities and muscle dysfunction result from the interaction of several factors, including tobacco smoking, low physical activity-sedentarism, systemic inflammation and the imbalance between energy supply and requirements, which essentially lead to a negative balance between protein breakdown and synthesis. Therapeutic approaches include improvements in lifestyle, nutritional supplementation and training. Anabolic drugs may be administered in some cases. UR - https://jtd.amegroups.org/article/view/19506