%0 Journal Article %T Lipoxin A4 regulates PM2.5-induced severe allergic asthma in mice via the Th1/Th2 balance of group 2 innate lymphoid cells %A Lu, Xiaoxia %A Fu, Huicong %A Han, Feng %A Fang, Yurong %A Xu, Jiali %A Zhang, Liqiong %A Du, Qing %J Journal of Thoracic Disease %D 2018 %B 2018 %9 %! Lipoxin A4 regulates PM2.5-induced severe allergic asthma in mice via the Th1/Th2 balance of group 2 innate lymphoid cells %K %X Background: Urban particulate matter (PM) contributes to the increasing number of people with asthma, which is closely related to the development of industrialization. Especially, PM with an aerodynamic diameter of Methods: In this study, we have investigated the effects of PM2.5 on ovalbumin (OVA)-induced asthma mice and the therapeutic effect of Lipoxin A4 (LXA 4 ) on improving the poor pathology. Results: The exposure of PM2.5 showed that both cytokines of T helper-2 (Th2) cells and transcription factors of group 2 innate lymphoid cells (ILC2s) were significantly increased, and inflammatory cell infiltration occurred in lung tissue. The LXA 4 was used to treat asthma, which was an effective option in reducing inflammatory cytokines and relieving pathological symptoms, probably by regulating the Th1/Th2 balance. Conclusions: These results suggest that PM2.5-induced inflammation plays a key role in the progression of asthma mice. In addition, LXA 4 has a significant therapeutic effect on asthma, which indicates the direction for the treatment of asthma related inflammatory diseases. %U https://jtd.amegroups.org/article/view/19895 %V 10 %N 3 %P 1449-1459 %@ 2077-6624