@article{JTD20489,
author = {Gu-Ha Alai and Han-Yu Deng and Gang Li and Jun Luo and Lun-Xu Liu and Yi-Dan Lin},
title = {The influence of heparin on coagulation function of patients undergoing video-assisted major thoracic surgery},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {4},
year = {2018},
keywords = {},
abstract = {Background: Venous thromboembolism (VTE) remains a common complication after major thoracic surgery, especially resection of lung or esophagus cancer. This trial aims to explore the influence of preoperative usage of heparin on coagulation function of patients treated with video-assisted major thoracic surgery.
Methods: This prospective randomized control trial collected 91 patients who are diagnosed with lung or esophagus cancer intending to accept video-assisted neoplasm resection from June 2016 to May 2017 in West China Hospital, Sichuan University. After admission to hospital, the patients received heparin sodium (unfractionated heparin) 5,000 U twice a day before operation. The change of blood platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), international normalized ratio (INR) was collected and analyzed at the points of admission to hospital and post-operation.
Results: The mean value of all coagulation parameters (PLT, PT, APTT, TT, INR, FIB) were in normal range both before and after operation. Postoperative PLT and FIB were not significantly different from preoperative PLT and FIB respectively (P>0.05). Preoperative PT, APTT, and INR increased significantly compared to pre-operation respectively (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/20489}
}