TY - JOUR AU - Skoczynski, Szymon AU - Wyskida, Katarzyna AU - Rzepka-Wrona, Patrycja AU - Wyskida, Magdalena AU - Uszok-Gawel, Ewa AU - Bartocha, Dawid AU - Krzych, Lukasz AU - Pierzchala, Wladysław AU - Barczyk, Adam PY - 2018 TI - Novel method of noninvasive ventilation supported therapeutic lavage in pulmonary alveolar proteinosis proves to relieve dyspnea, normalize pulmonary function test results and recover exercise capacity: a short communication JF - Journal of Thoracic Disease; Vol 10, No 4 (April 30, 2018): Journal of Thoracic Disease Y2 - 2018 KW - N2 - Whole lung lavage (WLL) under general anesthesia with a double-lumen endobronchial intubation has remained standard treatment option for pulmonary alveolar proteinosis (PAP) for over fifty years now. To the best of our knowledge, this is the first description of noninvasive ventilation (NIV) as an innovative alternative, which enables safe and effective treatment. NIV support enabled cost-effective lavage of the most affected segments and resulted in restoration and long-term maintenance of exercise capacity and diffusion, without WLL related hypoxaemia, volume overload, intubation, or mechanical ventilation related complications. The study presents all details of performed procedure, including anesthesia, NIV technique and bronchoscopy, therefore this may be easily implemented into clinical practice at other centers conducting PAP treatment. We assume that presented technique of therapeutic lung lavage (TLL) with NIV support may be considered a novel PAP treatment method, however, target population who will benefit the most from such therapy modification must be assessed in large scale prospective trials. UR - https://jtd.amegroups.org/article/view/20557