TY - JOUR AU - Liang, Hengrui AU - Pan, Zhenkui AU - Wang, Wei AU - Guo, Chengye AU - Chen, Difei AU - Zhang, Jianrong AU - Zhang, Yiyin AU - Tang, Shiyan AU - He, Jianxing AU - Liang, Wenhua AU - AME Lung Cancer Cooperative Group, written on behalf of PY - 2018 TI - The alteration of T790M between 19 del and L858R in NSCLC in the course of EGFR-TKIs therapy: a literature-based pooled analysis JF - Journal of Thoracic Disease; Vol 10, No 4 (April 30, 2018): Journal of Thoracic Disease Y2 - 2018 KW - N2 - Background: Treatment-naive epidermal growth factor receptor (EGFR) T790M mutation is more inclined to coexist with L858R than with 19 del in non-small cell lung cancer (NSCLC) patients. However, EGFR-tyrosine kinase inhibitors (EGFR-TKIs) might alter this status. We sought to compare the prevalence of T790M upon acquired resistance to EGFR-TKIs between 19 del and L858R by assembling all existing data. Methods: Electronic databases were comprehensively searched for eligible studies. The primary endpoint was the odds ratio (OR) of T790M mutation in NSCLC co-existing with L858R mutation and 19 del upon resistance to first-generation EGFR-TKIs. A random effects model was used. Stratified analysis was performed based on study type (retrospective and prospective), race (Asians and Caucasians) and sample type (tissue and plasma). Results: A total of 25 studies involving 1,770 patients were included. The overall T790M existent rate was 45.25%. Post-resistance T790M was more frequent in 19 del than in L858R mutated patients (53% vs . 36%; OR 1.87; P Conclusions: Opposite to the situation of de novo T790M, it was observed that T790M was more frequent in exon 19 deletion than in L858R among patients with acquired resistance to EGFR-TKIs. The difference in T790M alteration between 19 del and L858R encourages development of detection or treatment strategies for the specific resistance mechanism. UR - https://jtd.amegroups.org/article/view/20891